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Young Boys will again be without the services of Fabian Lustenberger and Jean-Pierre Nsame on Tuesday due to Achilles injuries, while Joel Monteiro, Esteban Petignat and Nico Maier will also be absent.
Aebischer’s double against Zurich on Saturday could see the 24-year-old feature in midfield, but there are expected to be a couple of changes from the weekend, with Mohamed Camara and Vincent Sierro in line to feature for the home side.
Young Boys are expected to line up in a 4-4-2 formation against the Red Devils, with Meschack Elia being joined in the final third by Theoson-Jordan Siebatcheu, and the pair have already scored six goals between them in the Swiss Super League this season.
Man United, meanwhile, will again be without the services of Marcus Rashford and Alex Telles, while Dean Henderson and Phil Jones have not made the trip despite recently recovering from their recent issues.
Scott McTominay was thought to be in contention, having made a quick return from groin surgery, but the Scotland international, who is not in the squad, has seemingly been saved for the West Ham clash. Fred, though, is in line to return to the midfield, having been an unused substitute against Newcastle due to the uncertainty surrounding his participation stemming from a FIFA suspension, which was ultimately lifted.
Solskjaer is expected to resist the temptation to rest Ronaldo following his two-goal performance on Saturday, and the Norwegian’s decision could be made easier by the fact that Edinson Cavani is still injured.
It would not be a surprise to see Paul Pogba moved to the left, dropping Jadon Sancho to the bench, but Solskjaer might feel that the England international needs minutes in his legs, so a very similar side could take to the field for the second successive match despite the relatively quick turnaround.
Young Boys possible starting lineup:
Von Ballmoos; Hefti, Camara, Zesiger, Garcia; Fassnacht, Sierro, Aebischer, Ngamaleu; Elia, Siebatcheu
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Fred, Pogba; Greenwood, Fernandes, Sancho; Ronaldo